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Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 1–4 of 4 articles · Keyword: Caveolae Clear keyword

Materials* (MDPI; inferred from format)2018ReviewDrug Delivery

1. Generation of Well-Defined Micro/Nanoparticles via Advanced Manufacturing Techniques for Therapeutic Delivery

Not Fully Listed In The Supplied File; Corresponding Authors Are P.Z. ([email protected]) And S.L. ([email protected])

Conventional micro/nanoparticle synthesis techniques (e.g., emulsion, sol–gel) can produce only a limited number of shapes—mainly spherical or rod-like—and provide poor control over size, cargo loading, and surface properties. These features critically affect particle–cell interactions and in vivo biodistribution, so…

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Chemical Society Reviews2017ReviewNon-viral Gene Delivery

2. Cellular Uptake of Nanoparticles: Journey Inside the Cell

Shahed Behzadi, Vahid Serpooshan, Wei Tao, Majd A. Hamaly, Mahmoud Y. Alkawareek, Erik C. Dreaden, Dennis Brown, Alaaldin M. Alkilany, Omid C. Farokhzad, Morteza Mahmoudi

Nanoparticles (NPs) are increasingly used in consumer goods, electronics, and pharmaceuticals, but their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. While many NPs require safe entry into cells for therapeutic efficacy, efficient and controlled…

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Cold Spring Harbor Perspectives in Biology2014ReviewNon-viral Gene Delivery

3. Clathrin-Independent Pathways of Endocytosis

Satyajit Mayor, Robert G. Parton, Julie G. Donaldson

Clathrin-mediated endocytosis (CME) has long been the dominant paradigm for cellular uptake, but many endocytic pathways operate without clathrin. These clathrin-independent endocytic (CIE) pathways are increasingly recognised as distinct routes with different cargo selectivity, molecular machinery, kinetics, and…

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Trends in Immunology2002ReviewNon-viral Gene Delivery

4. Caveolae and Caveolin in Immune Cells: Distribution and Functions

James Harris, Dirk Werling, Jayne C. Hope, Geraldine Taylor, Chris J. Howard

Caveolae and caveolin are cholesterol-rich membrane microdomains involved in endocytosis, cholesterol regulation, and signal transduction, but their presence and function in immune cells have been contentious. This review addresses the need to clarify the distribution and roles of caveolae/caveolin in mammalian…

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