Molecular medicine reports2026ReviewDrug Delivery
Liu H, Yan H, Liu S, Xue Y, Huang J, Li S
Graphene‑based nanomaterials have emerged as a versatile platform for tumour‑targeted drug delivery owing to their unique physicochemical properties, including large specific surface area, structural flexibility and tuneable surface chemistry. Graphene oxide (GO) and reduced GO have been extensively investigated as…
Read the article →Haematologica2026ResearchNon-viral Gene Delivery
Miesbach W, Pierce Gf
Among the inherited bleeding disorders, hemophilia B has become the leading target for adeno-associated virus (AAV) gene therapy. The compact factor IX (FIX) coding sequence, the abundance and durability of hepatocyte-derived FIX expression and the hyperactive FIX-Padua variant together made single-infusion…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Herdiana Y
Tuberculosis treatment remains prolonged because effective therapy must maintain coordinated multidrug exposure across heterogeneous lesions, bacterial states, and intracellular compartments. Long-acting nanomedicine may reduce adherence-related vulnerability and improve drug delivery, but prolonged release alone do…
Read the article →Molecular therapy. Advances2026ResearchNon-viral Gene Delivery
Ivan Dc, Dubost V, Israel L, Weinmann J, Ungan D, Carbonetti N, Et Al.
Efficient systemic delivery to the lung remains a major barrier for adeno-associated virus (AAV)-mediated pulmonary gene therapy, particularly when pre-existing immunity limits the use of conventional capsids. Here, we evaluated Bovine AAV, a phylogenetically divergent capsid, as a candidate vector for lung-directed…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Fu L, Wang L, Li H, Li R, Yue X, Cui Y, Et Al.
Metal-organic frameworks (MOFs) can coordinate copper, catalytic sites and therapeutic cargo within one carrier, offering opportunities to control copper exposure and cellular susceptibility. Establishing their contribution to cuproptosis requires evidence connecting these design functions to copper delivery and the…
Read the article →International journal of nanomedicine2026ResearchDrug Delivery
Chen Z, Liu Y, Jiang M, He X, Xiao M, Wu A, Et Al.
Nanoplatform-based combination therapy offers a promising route for enhanced cancer therapy. Despite the advance of nanomedicine, the precise subcellular co-delivery and controlled release of combinatorial therapeutic agents remain a significant challenge. Herein, a near-infrared (NIR)-responsive…
Read the article →Frontiers in cellular neuroscience2026ResearchNon-viral Gene Delivery
Reynolds Ss, Rasheed Mz, Niyonkuru K, Parikh S, Whyland K, Merrill Bm, Et Al.
Corneal innervation is essential for ocular surface homeostasis and protection, yet methods for selectively labeling and manipulating cornea-projecting neurons remain limited. Conventional retrograde tracers can identify cornea-projecting cell bodies in the trigeminal ganglion (TG), but they do not enable the…
Read the article →Frontiers in molecular neuroscience2026ReviewNon-viral Gene Delivery
Basu S, Demarest Tg, Gattone Nj, Gilsrud Aj, Wicks B, Khatiwada A, Et Al.
Biallelic loss-of-function mutations in PRKN gene (encoding Parkin protein) cause early-onset Parkinson's disease (EOPD). Parkin is a crucial component of the PINK1-Parkin pathway, which marks damaged mitochondria for degradation via mitophagy. Without functional Parkin, damaged mitochondria accumulate, causing…
Read the article →Cardiology in review2026ResearchNon-viral Gene Delivery
Karim A, Binte Imran S, Yousuf Ym, Asad D, Hassan Z, Rahman H, Et Al.
Advances in cardiovascular prevention and treatment have substantially improved patient outcomes. However, residual cardiovascular risk remains a major clinical challenge. Traditional lipid-lowering and antihypertensive therapies, although effective, remain limited by suboptimal adherence, adverse effects, and…
Read the article →American journal of human genetics2026ResearchNon-viral Gene Delivery
Kim-Mcmanus O, Goddard P, Olsson S, Protopsaltis L, Gleeson J, Zhang Q, Et Al.
Antisense oligonucleotides (ASOs) are versatile disease-modifying therapies for genetic diseases. An accelerated US Food and Drug Administration (FDA) pathway enables ASO treatment trial initiation in an individual within a year. However, this rapid N-of-1 pathway lacks extensibility to broad use necessary for…
Read the article →Exploration (Beijing, China)2026ReviewDrug Delivery
Lin Yj, Komperda I
Although nanomedicines offer advanced formulation control and physicochemical characterization, clinical translation has been limited. Delivery meta-analyses and late-stage attrition indicate biological validation is often a bottleneck. It must account for context-dependent processes such as protein corona formation…
Read the article →Computational biology and chemistry2026ResearchDrug Delivery
Alqahtani T, Alqahtani Am, Chidambaram K, Pradeep K, Murugesan V, Deshpande M, Et Al.
This work examines an exploratory screening and formulation workflow involving Rauwolfia serpentina alkaloids and Ajmaline-loaded solid lipid nanoparticles (SLNs). A Random Forest model was reported to reach 82.26% accuracy for ACE-associated activity classes and to classify 23 of 135 plant constituents as active…
Read the article →Journal of nanobiotechnology2026ResearchNon-viral Gene Delivery
Xiao Y, Hou X, Wei C, Ding M, Tan W, Tu P, Et Al.
Testicular dysfunction represents a leading cause of male infertility, yet effective therapeutic interventions remain elusive. Here, we report a novel plant-derived nanotherapeutic strategy for testicular injury using Cistanche deserticola-derived exosome-like nanovesicles (CDELNs).
Read the article →Drug development research2026ResearchNon-viral Gene DeliveryDrug Delivery
Cesur Ergun B, Demir-Dora D
Triple-negative breast cancer (TNBC) remains one of the most aggressive breast cancer subtypes owing to its high metastatic potential and the absence of effective molecularly targeted therapies. Although cRGD-functionalized nanocarriers have been extensively investigated for TNBC treatment, most reported systems…
Read the article →Biomaterials science2026ResearchNon-viral Gene DeliveryDrug Delivery
Dai Y, Zhou R, Zhang Y, Huang Z, Cheng H, Sun Q, Et Al.
Advances in gene delivery technologies have opened new avenues for modulating platelet function and expanding their applications in cell-based therapies. However, as anucleate cells, platelets have long faced the dual challenge of low transfection efficiency and susceptibility to activation during genetic…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Mcgranaghan Ct, Vankeulen-Miller R, Fenton Os, Mcerlean Em
Glioblastoma (GBM) is an aggressive and lethal primary brain malignancy, with patient survival largely unchanged over recent decades despite advances in surgery, radiotherapy and chemotherapy. A major therapeutic challenge is the blood-brain barrier (BBB), which restricts the delivery of many systemically…
Read the article →Molecular medicine reports2026ReviewNon-viral Gene Delivery
Qin R, Hu X, Jiang W, Wang J, Zheng M, Zhang Z, Et Al.
Genetic epilepsy, for which the molecular mechanisms are relatively well defined in numerous monogenic forms, represents an attractive model for the transition from symptomatic seizure control to mechanism‑driven correction. However, gene therapy strategies differ in their mechanisms of action, adaptability to…
Read the article →Colloids and surfaces. B, Biointerfaces2026ReviewDrug Delivery
Maiti S, Maji B, Lakra P
Natural antioxidant-integrated amphiphilic chitosan has emerged as a promising platform for advanced drug delivery and cancer therapy, supporting sustainable and eco-friendly nanomedicine development. This review summarizes recent progress in the design, chemistry, physicochemical properties, and chemotherapeutic…
Read the article →ACS omega2026ResearchNon-viral Gene DeliveryDrug Delivery
Xu Y, Vest O, Brooks B, Mcneal J, Jansen Ma, He J, Et Al.
Clinical translation of carbon nanotube (CNT)-based biomedical technologies requires a comprehensive understanding of scalable manufacturing, in vivo behavior, and dose efficiency. Here, we investigate NanoVac, a vaccine delivery platform based on functionalized short carbon nanotubes (SCNTs). We achieved scalable…
Read the article →Progress in biophysics and molecular biology2026ReviewNon-viral Gene Delivery
Boretti A
CRISPR-Cas9 genome editing has transformed biomedical research and is advancing toward clinical translation. The integration of artificial intelligence (AI) offers improved precision in guide RNA design, off-target prediction, and delivery optimization. This review synthesizes recent advances in CRISPR-Cas9 for…
Read the article →Current opinion in chemical biology2026ReviewNon-viral Gene DeliveryDrug Delivery
Deagazio C, Singh A, Banskota S
Genome editing technologies hold significant promise for the treatment of genetic disorders, but safe and efficient delivery remains a major barrier to their clinical translation. Cell-derived particles, including extracellular vesicles (EVs) and virus-like particles (VLPs), have emerged as promising non-viral…
Read the article →Journal of liposome research2026ResearchDrug Delivery
Budharam S, Shivally Boregowda S, Binsuwaidan R, Adnan M, Alshammari N, Almarshadi F, Et Al.
Eletriptan HBr-loaded solid lipid nanoparticles (ESLN) were designed for brain delivery by circumventing first-pass metabolism and the blood-brain barrier. The formulation combines biocompatible polymers with the permeability-enhancing properties of lipids. A central composite design was employed to optimize…
Read the article →International journal of biological macromolecules2026ResearchNon-viral Gene Delivery
Shin Hg, Yang Hr, Hwang Jh, Cho Hr, Hwang K, Lee S
Triple-negative breast cancer (TNBC) poses a significant therapeutic challenge because it has limited actionable molecular targets. Trophoblast cell-surface antigen 2 (TROP2) is a promising therapeutic target, overexpressed in approximately 80% of TNBC cases. However, conventional recombinant adeno-associated virus…
Read the article →ACS applied bio materials2026ResearchDrug Delivery
Campion T, Lordon B, Alauzet L, Wodrinski A, Fourquaux I, Putaux Jl, Et Al.
Polymer micelles based on poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-PCL) are widely investigated as nanocarriers for photodynamic therapy (PDT) due to their ability to solubilize hydrophobic photosensitizers such as pheophorbide a and enhance their delivery. In this study, we systematically assessed the…
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