Current drug targets2026ResearchDrug Delivery
Sharma S, Nag P, Vij K, Kalra A, Goel K
Neurological problems are among the world's most significant health issues. Many conditions are considered incurable because current treatments cannot effectively cross the Blood-Brain Barrier (BBB) to exert pharmacological effects. Nanomedicine utilizing various nanoparticles offers a distinct therapeutic approach…
Read the article →bioRxiv : the preprint server for biology2026ResearchNon-viral Gene Delivery
Sairavi A, Das R, Li L, Groat T, Matsuzaki Y, Hirai H, Et Al.
Genetic kidney diseases are promising targets for gene therapy. Emerging AAV capsids that reportedly enable effective gene delivery to proximal tubules (PTs) following intravenous injection have raised hopes for treating diseases affecting renal tubules. Despite these promising developments, the scientific literature…
Read the article →International journal of pharmaceutics: X2026ResearchNon-viral Gene DeliveryDrug Delivery
Kim Kh, Mainali A, Pih Sh, Jung Hs, Kim Hj, Kim Na, Et Al.
RNA-loaded lipid nanoparticles (LNPs) are highly sensitive to temperature fluctuations, which present significant challenges for storage and transportation. Lyophilization is a potential strategy to enhance storage stability; however, the freeze-drying process can subject nanoparticles to stresses that may alter…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Chauhan A, Kamal R, Kumar M, Awasthi A, Kumar D, Choudhary N, Et Al.
Nanoemulsions (NEs) are kinetically stable, thermodynamically unstable colloidal systems composed of nanoscale oil and aqueous domains stabilized primarily by surfactants and, where required, co-surfactants. Their small droplet size, large interfacial area, and tunable physicochemical properties provide opportunities…
Read the article →MedComm2026ReviewNon-viral Gene DeliveryDrug Delivery
Kamra K, Gaur S, Singh J
Respiratory diseases remain major causes of morbidity and mortality; however, inadequate pulmonary drug exposure and systemic toxicity continue to limit treatment efficacy. Inhaled nanomedicines offer opportunities for localized, sustained, and targeted therapy. This review examines how disease biology informs…
Read the article →Discover nano2026ReviewNon-viral Gene DeliveryDrug Delivery
Manna P, Maity A, Roy S, Sahu S, Pradhan S, Ganguly Sc, Et Al.
Alzheimer's disease, being a complicated neurodegenerative disoder affects cognitive as well as memory functions. Characterised by amyloid-β aggregation, along with tau hyperphosphorylation, and cholinergic dysfunction, this disease is also associated with oxidative stress and neuroinflammation. Conventional clinical…
Read the article →Chemical communications (Cambridge, England)2026ReviewDrug Delivery
Yi Jy, Kim Ym, Tang T, Noh H, Hong S
Nanobodies are compact single-domain antibody fragments distinguished by their high stability, tissue-penetrating ability, and ease of molecular engineering. As the smallest naturally occurring antigen-binding domains, they have considerable potential as targeting ligands for precision drug delivery. In parallel…
Read the article →Current gene therapy2026ResearchNon-viral Gene DeliveryDrug Delivery
Rajeshwar V, Kumar Kr, Kumar Gr, Roja P, Mohan Vk, Aparna Tn
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPRassociated protein 9 (Cas9) system has revolutionized genome editing through its precision, simplicity, and programmability. The clinical translation of CRISPR/Cas9 Ribonucleoproteins (RNPs) remains constrained by major delivery challenges…
Read the article →ACS applied materials & interfaces2026ResearchNon-viral Gene DeliveryDrug Delivery
Quagliarini E, Petronella F, Digiacomo L, Miglietta S, Buccini L, Mura F, Et Al.
Gene therapy is a cutting-edge strategy for treating, preventing, and potentially eradicating a wide range of diseases. Its success is critically dependent on the transfection efficiency of gene delivery systems. In this context, lipid nanoparticles (LNPs) are widely investigated for the delivery of plasmid DNA…
Read the article →Acta pharmaceutica Sinica. B2026ResearchNon-viral Gene DeliveryDrug Delivery
Li S, Zhang Y, Han Y, Zhao M, Wang Y, Lu J, Et Al.
Neutrophils exhibit significant plasticity within the tumor microenvironment (TME), such as promoting immune suppression, tumor growth, and metastasis. Although various nano drug delivery systems targeting neutrophils have been developed based on their tumor chemotaxis, few studies have focused on designing…
Read the article →The CRISPR journal2026ResearchNon-viral Gene Delivery
Sharma A, Seo Y, Park Ts
Genome editing has been revolutionized by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9) technology. However, efficient intracellular delivery of Cas9 ribonucleoprotein (RNP) remains a major challenge, particularly in cells that are refractory to conventional…
Read the article →Nature nanotechnology2026ResearchNon-viral Gene DeliveryDrug Delivery
Tian M, Wang L, Liu Z, Cao D, Yu C, Bennett Jl, Et Al.
Effective delivery of RNA therapeutics to the brain remains challenging due to the multiple barriers of the central nervous system (CNS). To probe molecular scaffolds that could help overcome these barriers, we analysed the pharmaceutical profiles of over 100 CNS-active drugs and identified hydroxyzine (HX) as a…
Read the article →Frontiers in immunology2026ReviewNon-viral Gene DeliveryDrug Delivery
Li L, Wu M, Li L
Glioma, particularly glioblastoma, remains difficult to treat because of limited drug penetration across the blood-brain barrier, profound immune suppression, and insufficient intracranial exposure of systemic immunotherapies. Intranasal nano-immunotherapy is being explored as a potential strategy that may integrate…
Read the article →Epigenomics2026ReviewNon-viral Gene DeliveryDrug Delivery
Mustafa Am, Kareem Si, Raouf Cg, Ahmed Sm
The clinical validation of mRNA-based COVID-19 vaccines in 2020-2021 accelerated the development of synthetic messenger RNA as a precision therapeutic platform beyond infectious disease prevention. Unlike gene therapy approaches that permanently modify genomic DNA, synthetic mRNA enables transient protein expression…
Read the article →European journal of haematology2026ReviewNon-viral Gene DeliveryDrug Delivery
Morabito F, Martino Ea, Bruzzese A, Amodio N, Caserta S, Lucia E, Et Al.
mRNA-based vaccines are emerging as a promising platform for cancer immunotherapy, including in hematologic malignancies. Current vaccine development has largely focused on antigen selection, mRNA engineering, lipid nanoparticle (LNP) formulation, and combination with established immunotherapies. However, increasing…
Read the article →Nature communications2026ResearchNon-viral Gene DeliveryDrug Delivery
Cao D, Tian M, Yu C, Xue Y, Liu Z, Zhong Y, Et Al.
Inflammatory bowel disease (IBD) is an incurable disorder that requires long-term management, which is limited by suboptimal efficacy and systemic toxicity of current treatments. We developed a series of glucocorticoid-derived ionizable lipids and formulated them into lipid nanoparticles (LNPs) for rectal and…
Read the article →Biotechnology and bioengineering2026ResearchNon-viral Gene Delivery
Müller Jm, Tobler D, Bühler J, Hauri D, Plieninger R, Göbel S, Et Al.
Recombinant adeno-associated viruses (rAAVs) have gained increasing importance in gene therapy due to their safe and precise gene delivery. However, certain indications require substantially higher vector doses, pushing manufacturing capacity and cost of goods (COG) to its limits. In this study, we present a…
Read the article →Chembiochem : a European journal of chemical biology2026ReviewDrug Delivery
Joshi N, Semwal P, Rawat B, Kumar R, Oliveira Ms, Rai N, Et Al.
Shikonin (SHK) is a red naphthoquinone produced mainly in the roots of Boraginaceae species and has been investigated for anticancer, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective, hepatoprotective, and wound-healing activities. This review critically integrates botanical sources and…
Read the article →Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery
Kehrein J, Reus E, Holick Ct, Mummel S, Ates I, Wang X, Et Al.
Delivering therapeutic mRNA relies on lipid nanoparticles (LNPs). Finding optimal process parameters for new lipid combinations in LNP formulations remains a challenge. We used an automated, self-regulating microfluidic formulation platform developed for PEG-containing LNPs that actively changes process parameters to…
Read the article →Nanomedicine (London, England)2026ResearchDrug Delivery
Tunc Cu, Saha Sk, Panda Ss, Mori S, Culha M
DNA nanotechnology has emerged as a highly programmable platform in nanomedicine, enabling the fabrication of precise nanoscale architectures for drug delivery, biosensing, gene regulation, immunotherapy, and theranostics. DNA-based nanocarriers offer distinctive advantages, including structural programmability…
Read the article →Current pharmaceutical design2026ResearchDrug Delivery
Babar E, Ur Rehman A, Gul P, Arshad Ms, Shah Ba, Ahmed N
Alzheimer's disease affects millions of people globally; it is an irreversible and incurable disease, characterized by gradual cognitive decline as well as pathophysiological changes including the presence of senile plaques and neurofibrillary tangles. There are several risk factors associated with Alzheimer's…
Read the article →ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery
Fiedler Bm, Galley C, Strimaite M, Cheng Nm, Mahmoudi N, Feng Z, Et Al.
Following the successes of the messenger RNA (mRNA) lipid nanoparticle (LNP) vaccines against COVID-19, mRNA-LNPs are being explored for varied multidose applications including cancer immunotherapies and protein replacement therapies. LNPs rely on poly(ethylene glycol)-lipid (PEG-lipid) coatings for stability, but…
Read the article →Gene therapy2026ResearchNon-viral Gene Delivery
Lyu P, Bostanci A, Jiang C, Yoo Kw, Broadhurst R, Atala A, Et Al.
Dent disease type 1 is a rare X-linked renal tubulopathy caused by loss of the Cl⁻/H⁺ exchanger ClC-5, leading to defective proximal tubular endocytosis and low-molecular-weight proteinuria. Viral gene therapy represents a promising disease-modifying strategy; however, the relative performance of integrating versus…
Read the article →International journal of nanomedicine2026ReviewNon-viral Gene DeliveryDrug Delivery
Altahla R, Wang Y, Morshedi Yekta M, Wang Z, Jiang H, Li C, Et Al.
Cancer nanomedicine offers programmable platforms for diagnosis, imaging, drug and gene delivery, and theranostics, but its clinical performance is constrained by tumor heterogeneity, complex nano-bio interactions, and interpatient variability. Artificial intelligence (AI) provides a means to integrate…
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