Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.
706 articles
Showing 1–16 of 16 articles · Keyword: Clinical translation Clear keyword
Ma X, Li L, Sun Y
CRISPR-Cas genome editing represents one of the most transformative advances in modern molecular biology, enabling programmable site-specific genetic modification that has revolutionized functional genomics and precision therapeutic development. Beyond canonical Cas9 nucleases, the CRISPR toolkit has diversified into…
Read the articleFu M, Zhao R, Cao Y, Nan Y, Fan L, Liu Z
Gynecological cancers, including ovarian, cervical, and endometrial cancers, remain major contributors to female morbidity and mortality worldwide. Conventional treatments-surgery, chemotherapy, and radiotherapy-have improved outcomes, but advanced or recurrent disease is still associated with poor prognosis…
Nagdev S, Tantray J, Yadav Mk, Patel A, Sharma S, Singh Ak, Et Al.
Pancreatic cancer is among the most prevalent ones, and its diagnosis typically occurs in the latter stages. Traditional chemotherapy is usually limited by low tumour penetration, systemic toxicity, and drug resistance. The new method of drug delivery utilizing nanotechnology has proven an effective strategy for…
Read the articleKaur S, Harish V, Bashir B, Kolekar Ka, Singh Sk
Exosomes have been described as emerging nanocarriers that have potential for the targeted delivery of therapeutics. They offer many advantages over traditional drug delivery systems, such as their intrinsic biocompatibility, low immunogenicity, and prolonged circulation, as well as crossing biological barriers. This…
Read the articleLi Y, Gong Y, Li X, Yan S, Yu J, Qiu Z, Et Al.
Hepatic fibrosis (HF) is a pathological wound-healing response to chronic liver injury that can progress to cirrhosis and hepatocellular carcinoma. Although resmetirom and semaglutide have been approved for noncirrhotic metabolic dysfunction-associated steatohepatitis with fibrosis, they are restricted to a single…
Bu F, Cao Y, Chen F, Wen Y, Xiong L
Reperfusion therapy has transformed acute ischemic stroke care, yet large-vessel recanalization does not ensure capillary reperfusion, preservation of the blood-brain barrier and neurovascular unit (BBB/NVU), or durable neurological recovery. Nanomedicine is still commonly judged by BBB crossing or…
Pan Y, Wang R, Qin S, Zhao L, Xing X
Curcumin has diverse pharmacological activities but poor water solubility, rapid degradation, extensive metabolism, and very low oral bioavailability limit its therapeutic use. This review evaluates mesenchymal stem cell-derived exosomes (MSC-Exo; MSC-derived small extracellular vesicles per MISEV2023) as natural…
Acharya R, Komedchikova E, Choi Y, Yang J, Kim J, Son J, Et Al.
Biological barriers are essential for maintaining tissue homeostasis and protecting organs from harmful external agents; however, they also represent major obstacles to the efficient delivery of therapeutic agents. The blood-brain barrier, ocular barriers, mucosal barriers, and vascular endothelial barriers exhibit…
Sun M, Xiao L, Yu Y
Neoantigen vaccines have become an important direction in cancer immunotherapy because mutation-derived tumor antigens can induce highly specific T-cell responses while minimizing immune tolerance associated with tumor-associated antigens. However, their therapeutic performance remains limited by several…
Read the articleGawale K, Karawadiya A, Katawale S, Sawarkar S, Omri A
Antimicrobial resistance (AMR) represents a critical global health threat, surpassing the pace of discovery and clinical development of new antimicrobial agents. Therefore, innovative therapeutic strategies are urgently needed to enhance antibiotic efficacy, overcome multidrug-resistant infections, and limit…
Sescu Va, Condriuc Ips, Spridon Lg, Cadinoiu An, Miron L, Atanase Li, Et Al.
Breast cancer is the most frequently diagnosed malignancy worldwide and remains a major cause of cancer-related mortality among women. Despite advances in screening, molecular classification, and systemic therapies, treatment of advanced and metastatic disease remains challenging because of tumor heterogeneity…
Wang W, Song J, Du Y, Zhou C, Zuo X, You G, Et Al.
Due to the increasing demand for clinical gene therapy and the limitations of current treatment methods, there is an urgent need to develop gene-editing tools that are safer, more precise, and more clinically implementable. Deaminase-based base editors have emerged as gene-editing platforms with significant…
Gharatape A, Alikhanian A, Verdi J, Choonara Ye, Faridi-Majidi R
Although therapeutic opportunities beyond the scope of either field alone are offered by the combination of immune cell treatment and nanotechnology, a dominant nanoparticle design for immune-cell engineering has not been yielded by two decades of research. Here, it is contended that this lack of advancement is the…
Yuan Y, Xie C, Huang Y, Xi J, Wang P, Chen Z, Et Al.
Stroke ranks among the leading global causes of mortality and permanent disability. Its secondary brain injury arises from multiple interrelated pathological cascades, including oxidative stress, neuroinflammation, disrupted autophagy-apoptosis balance, excitotoxicity, iron dyshomeostasis, and blood-brain barrier…
Read the articleKausar T, Ahmed W, Shafiq T, Kausar R, Liang Y, Duan L
Nanomedicine represents one of the pivotal technologies that further bridges critical gaps in precision theranostics through targeted delivery, integrated diagnostics and therapeutics, and personalized treatment. Among various nanocarriers, extracellular vesicles (EVs) have attracted substantial interest owing to…
Cm Jogdeo, K Siddhanta, A Das, L Ding, S Panja, N Kumari, D Oupický
A review of polymer-based alternatives to lipid gene delivery, including polyplexes and polymer–nucleic acid conjugates, with attention to chemical tunability and clinical translation.
We co-develop nanocarrier and biosensing programmes with pharma, biotech and academic groups — from target selection through scale-up.
