Discover nano2026ReviewNon-viral Gene DeliveryDrug Delivery
Aadil Kr, Bhange K, Kommineni N, Mishra G, Bunekar N, Jha A, Et Al.
Messenger RNA (mRNA)-based therapeutics have transformed cancer treatment strategies, especially after the success of lipid nanoparticle (LNP)-enabled mRNA vaccines. LNPs are effective non-viral delivery vehicles that protect mRNA, enhance intracellular delivery, and improve therapeutic safety. This review discusses…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Lai Gy, Hsieh Ysy, Lee Mh
Plant-derived herbal medicines remain important sources of bioactive compounds, but their clinical application is often hindered by poor bioavailability and variable pharmacokinetic profiles. Recent studies have identified plant-derived exosome-like nanoparticles (PELNs) as naturally occurring bioactive nanoparticle…
Read the article →Frontiers in immunology2026ReviewNon-viral Gene DeliveryDrug Delivery
Ganjalikhani Hakemi M, Saltanatpori Z, Zhou L, Zeng X, Sun L, Liao Z
Chimeric antigen receptor-engineered natural killer (CAR-NK) cell therapy has emerged as a promising cancer treatment by combining the antigen specificity of CAR engineering with the intrinsic cytotoxicity of NK cells. Compared with CAR-T cell therapy, CAR-NK cells exhibit a lower risk of graft-versus-host disease…
Read the article →Frontiers in pharmacology2026ReviewDrug Delivery
Inam M, Hayat M, Latif F, Ahmed B, Osman A
Endometriosis is a chronic inflammatory condition for which existing treatments, mainly hormonal therapy and surgical intervention, remain insufficient. These approaches are often limited by high recurrence rates, significant side effects, and an inability to effectively target underlying disease mechanisms. This…
Read the article →Discover nano2026ReviewDrug Delivery
Parseghian L, Sanadgol N, Negah Ss, Fahanik-Babaei J, Rafati H
Efficiently delivering therapeutics to the central nervous system (CNS) remains a major challenge in multiple sclerosis (MS), particularly for strategies targeting CNS-resident pathology, neuroprotection, or remyelination. This review provides a delivery- and formulation-centered comparative analysis of CNS drug…
Read the article →Expert opinion on drug delivery2026ReviewDrug Delivery
Hernandez Pa, Moore Cj, Overby Ct, Benoit Dsw
Nanoparticle drug delivery systems (NP DDS) have transformed therapeutic delivery by improving drug stability, extending circulation time, and enabling targeted biodistribution. However, clinical translation remains limited by protein corona formation, immune recognition, and accelerated blood clearance following…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Herdiana Y
Tuberculosis treatment remains prolonged because effective therapy must maintain coordinated multidrug exposure across heterogeneous lesions, bacterial states, and intracellular compartments. Long-acting nanomedicine may reduce adherence-related vulnerability and improve drug delivery, but prolonged release alone do…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Fu L, Wang L, Li H, Li R, Yue X, Cui Y, Et Al.
Metal-organic frameworks (MOFs) can coordinate copper, catalytic sites and therapeutic cargo within one carrier, offering opportunities to control copper exposure and cellular susceptibility. Establishing their contribution to cuproptosis requires evidence connecting these design functions to copper delivery and the…
Read the article →Exploration (Beijing, China)2026ReviewDrug Delivery
Lin Yj, Komperda I
Although nanomedicines offer advanced formulation control and physicochemical characterization, clinical translation has been limited. Delivery meta-analyses and late-stage attrition indicate biological validation is often a bottleneck. It must account for context-dependent processes such as protein corona formation…
Read the article →Chembiochem : a European journal of chemical biology2026ReviewDrug Delivery
Joshi N, Semwal P, Rawat B, Kumar R, Oliveira Ms, Rai N, Et Al.
Shikonin (SHK) is a red naphthoquinone produced mainly in the roots of Boraginaceae species and has been investigated for anticancer, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective, hepatoprotective, and wound-healing activities. This review critically integrates botanical sources and…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Bu F, Cao Y, Chen F, Wen Y, Xiong L
Reperfusion therapy has transformed acute ischemic stroke care, yet large-vessel recanalization does not ensure capillary reperfusion, preservation of the blood-brain barrier and neurovascular unit (BBB/NVU), or durable neurological recovery. Nanomedicine is still commonly judged by BBB crossing or…
Read the article →Expert review of anti-infective therapy2026ReviewNon-viral Gene DeliveryDrug Delivery
Gawale K, Karawadiya A, Katawale S, Sawarkar S, Omri A
Antimicrobial resistance (AMR) represents a critical global health threat, surpassing the pace of discovery and clinical development of new antimicrobial agents. Therefore, innovative therapeutic strategies are urgently needed to enhance antibiotic efficacy, overcome multidrug-resistant infections, and limit…
Read the article →The Journal of pharmacy and pharmacology2026ReviewDrug Delivery
Dubey S, Prakash S, Deshwal Rk, Dwivedi M
Cancer remains a major global health challenge despite significant advances in diagnosis and treatment. Conventional therapies, including chemotherapy, radiotherapy, and surgery, are frequently constrained by non-specific drug distribution, systemic toxicity, multidrug resistance (MDR), and limitations in early tumor…
Read the article →Cancers2026ReviewNon-viral Gene DeliveryDrug Delivery
Sescu Va, Condriuc Ips, Spridon Lg, Cadinoiu An, Miron L, Atanase Li, Et Al.
Breast cancer is the most frequently diagnosed malignancy worldwide and remains a major cause of cancer-related mortality among women. Despite advances in screening, molecular classification, and systemic therapies, treatment of advanced and metastatic disease remains challenging because of tumor heterogeneity…
Read the article →ACS Nano2021ReviewDrug Delivery
Paula M. Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R. Lewin, Christina Cortez-Jugo, Frank Caruso
T cells are attractive targets for immunotherapy, cancer, HIV, autoimmunity, and inflammation, but nanoparticle delivery to T cells remains a major technological challenge due to their nonphagocytic nature and multiple physiological barriers. There is a need for rational design principles for in vivo T cell-targeting…
Read the article →Chemical Society Reviews2017ReviewNon-viral Gene Delivery
Shahed Behzadi, Vahid Serpooshan, Wei Tao, Majd A. Hamaly, Mahmoud Y. Alkawareek, Erik C. Dreaden, Dennis Brown, Alaaldin M. Alkilany, Omid C. Farokhzad, Morteza Mahmoudi
Nanoparticles (NPs) are increasingly used in consumer goods, electronics, and pharmaceuticals, but their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. While many NPs require safe entry into cells for therapeutic efficacy, efficient and controlled…
Read the article →Pharmaceutical Research2011ReviewNon-viral Gene Delivery
Wei-Yun Sheng, Leaf Huang
The immune system can recognise and kill pre-cancer and cancer cells, but surviving tumour cells learn to escape immune surveillance after immunoselection. Cancer immunotherapy aims to overcome these escape mechanisms. Nanomedicine offers tools—nanodiagnostics and nanobiopharmaceuticals—to deliver antigens…
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