Frontiers in immunology2026ReviewDrug Delivery
Liu J, Yang Y, Zhang W, Liu J, Yu Y, Song Y, Et Al.
Natural killer (NK) cells are essential components of innate immunity and play a pivotal role in tumor surveillance through direct cytotoxicity and immune regulation. In recent years, NK-cell-derived extracellular vesicles (NK-EVs) have emerged as a promising cell-free therapeutic modality that preserves key…
Read the article →Journal of nanobiotechnology2026ReviewDrug Delivery
Sun M, Xiao L, Yu Y
Neoantigen vaccines have become an important direction in cancer immunotherapy because mutation-derived tumor antigens can induce highly specific T-cell responses while minimizing immune tolerance associated with tumor-associated antigens. However, their therapeutic performance remains limited by several…
Read the article →Expert opinion on drug delivery2026ReviewDrug Delivery
Gelperina S, Wacker Mg
Apolipoprotein E (apoE) plays a context-dependent role in nanomedicine for central nervous system drug delivery. It can facilitate cerebral endothelial recognition and increase brain exposure in nanoparticle systems while simultaneously promoting hepatic uptake, challenging its traditional interpretation as a…
Read the article →Expert review of anti-infective therapy2026ReviewNon-viral Gene DeliveryDrug Delivery
Gawale K, Karawadiya A, Katawale S, Sawarkar S, Omri A
Antimicrobial resistance (AMR) represents a critical global health threat, surpassing the pace of discovery and clinical development of new antimicrobial agents. Therefore, innovative therapeutic strategies are urgently needed to enhance antibiotic efficacy, overcome multidrug-resistant infections, and limit…
Read the article →Beilstein journal of nanotechnology2026ReviewDrug Delivery
Yao Y, Nafo W
We reviewed artificial intelligence and machine learning in magnetic resonance imaging-visible magnetic nanoparticles, nanocarriers, and systems for imaging, drug delivery, hyperthermia, targeting, transport, and control. Using "preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020"…
Read the article →Frontiers in genome editing2026ReviewNon-viral Gene Delivery
Liu Hb, Kumar T, Abu-Ellail Ffb, Lin Xq, Li Cj, Xu Ch, Et Al.
Sugar crops including sugarcane, sugar beets, and sweet sorghum, are fundamental for global sucrose supply and crucial feedstocks for bioethanol production and industrial bioproducts. However, yield and sucrose accumulation are significantly influenced by abiotic stresses, including drought, salinity/alkalinity…
Read the article →Pharmaceutics2026ReviewNon-viral Gene DeliveryDrug Delivery
Bonanno C, Romeo G
Background/Objectives: MicroRNAs (miRNAs) are small non-coding RNAs (20-24 nucleotides) that regulate post-transcriptional gene expression and are involved in key biological processes, including proliferation and apoptosis. Dysregulation of miRNA expression is associated with numerous diseases, particularly cancer…
Read the article →International journal of molecular sciences2026ReviewNon-viral Gene DeliveryDrug Delivery
Wang Y, Wang S, Wang H
Antibody-oligonucleotide conjugates (AOCs) are usually viewed as delivery vehicles that carry nucleic-acid payloads to defined cell populations for gene silencing or gene regulation. Existing reviews concentrate on delivery systems, tumour-directed therapy and extrahepatic oligonucleotide delivery, while the…
Read the article →Frontiers in drug delivery2026ReviewDrug Delivery
Li X, Zhang H, Ding R, Wang F
Metal-organic frameworks and covalent organic frameworks offer a rare opportunity to design drug carriers from molecular building blocks upward. Yet high loading capacity and stimulus-responsive release alone do not constitute precision delivery. We critically synthesized evidence on MOF and COF pore-level cargo…
Read the article →Pharmaceutics2026ReviewDrug Delivery
Syed Hashim Sa
Clinical translation of lipid nanomedicines in oncology is limited by biological barriers and by an interpretive challenge: tumour accumulation and cellular uptake are often used as proxies for delivery even when pharmacologically competent cargo, meaning cargo capable of producing its intended molecular effect, has…
Read the article →Pharmaceutics2026ReviewNon-viral Gene DeliveryDrug Delivery
Ommi O, Covarrubias-Zambrano O, Bossmann Sh, Kamath D
Background/Objectives: Peptide-functionalized polymeric nanocarriers are redefining targeted cancer therapy by combining the molecular specificity of peptides with the structural versatility of polymers. This review aims to highlight recent advances in peptide-functionalized polymeric nanocarrier systems designed to…
Read the article →The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2026ReviewNon-viral Gene DeliveryDrug Delivery
Olm F, Kortleven P, Mittendorfer M, Carlon Ms, Ceulemans Lj, Lindstedt S
Lung transplantation (LTx) remains the only definitive therapy for selected patients with end-stage lung disease, yet outcomes are limited by early ischemia-reperfusion injury (IRI) and primary graft dysfunction (PGD), and by chronic lung allograft dysfunction (CLAD) as the leading cause of late graft failure.
Read the article →Biomaterials science2026ReviewNon-viral Gene DeliveryDrug Delivery
Xiao Y, Tong X, Wang Z, Zhang Y, Liu S, Tian M, Et Al.
mRNA has emerged as a star molecule in pharmaceutical development, demonstrating immense potential for the diagnosis and treatment of cancer, neurological disorders, genetic diseases, and infectious diseases. It has played a particularly pivotal role in COVID-19 prevention. However, the clinical translation of mRNA…
Read the article →Molecules (Basel, Switzerland)2026ReviewDrug Delivery
Lee M, Choi Y, Yoon Sj, Kim M
Extracellular vesicles (EVs) have emerged as promising therapeutic carriers owing to their biocompatibility, low immunogenicity, and ability to transport diverse biological cargo. However, successful EV-based therapy depends not only on carrier engineering but also on selecting an administration route appropriate for…
Read the article →Pharmaceutics2026ReviewDrug Delivery
Jacob S, Varkey Nr, Rao R, Shinu P, Khanam R
Biomimetic cell membrane-coated nanoparticles (CM-NPs) have emerged as a promising class of nanocarriers that integrate the tunable physicochemical properties of engineered nanoparticles with selected biological features of naturally derived cell membranes.
Read the article →Pharmaceutics2026ReviewDrug Delivery
Ban M, Zhao S, Liu Z, Zhao L
Cancer remains a major global health challenge, and nanoparticle-based drug delivery systems have emerged as a promising strategy for targeted cancer therapy. However, clinical translation is still limited by an incomplete understanding of how nanoparticles navigate the tumor microenvironment (TME) throughout the…
Read the article →Molecular therapy. Advances2026ReviewNon-viral Gene Delivery
Keating Al, Carlisle Rc, Mitrophanous Ka, Seymour Lw, Fisher Kd
Lentiviral vector (LVV)-mediated chimeric antigen receptor (CAR)-T cell therapy has transformed the landscape for blood cancer treatment through genetic modification of patients' T cells. Yet, the complexity of the manufacturing process makes this therapy inaccessible for many patients. Systemic intravenous delivery…
Read the article →International journal of nanomedicine2026ReviewNon-viral Gene DeliveryDrug Delivery
Tang X, Huang Y, Zhang X, He C
Ovarian cancer is one of the most lethal gynecological malignancies. Its immunosuppressive tumor microenvironment and peritoneal dissemination characteristics have severely limited the efficacy of existing immunotherapies. To overcome the poor immunogenicity of tumor antigens and the need for coordinated delivery of…
Read the article →Molecular therapy. Oncology2026ReviewNon-viral Gene DeliveryDrug Delivery
Bedada At, Genet S
Cancer remains a formidable global health challenge, representing the second leading cause of mortality worldwide. In 2023, there were approximately 18.5 million new cancer cases and over 10 million deaths globally, with projections estimating 30.5 million new cases and 18.6 million deaths annually by 2050. In the…
Read the article →International journal of molecular sciences2026ReviewNon-viral Gene DeliveryDrug Delivery
Rachamala Hk, Angom Rs, Marepally S
In recent years, lipid nanoparticles (LNPs) have shown great promise as highly flexible delivery systems for cancer vaccines, which enable effective cargo delivery and allow for controlling their distribution, cell-targeting ability and immunogenicity. Innovations in ionizable lipid chemistry, biodegradable…
Read the article →The Journal of pharmacy and pharmacology2026ReviewDrug Delivery
Dubey S, Prakash S, Deshwal Rk, Dwivedi M
Cancer remains a major global health challenge despite significant advances in diagnosis and treatment. Conventional therapies, including chemotherapy, radiotherapy, and surgery, are frequently constrained by non-specific drug distribution, systemic toxicity, multidrug resistance (MDR), and limitations in early tumor…
Read the article →Cancers2026ReviewNon-viral Gene DeliveryDrug Delivery
Sescu Va, Condriuc Ips, Spridon Lg, Cadinoiu An, Miron L, Atanase Li, Et Al.
Breast cancer is the most frequently diagnosed malignancy worldwide and remains a major cause of cancer-related mortality among women. Despite advances in screening, molecular classification, and systemic therapies, treatment of advanced and metastatic disease remains challenging because of tumor heterogeneity…
Read the article →Biomedicines2026ReviewNon-viral Gene DeliveryDrug Delivery
Duffy A, Schweikert A, Tan Sy, Murphy C, Dowling Cm, Hurley K, Et Al.
Chronic lung diseases arise from complex interactions between environmental exposures and host genetic factors. However, these interactions are not fully understood, and despite decades of study, effective curative therapies remain unavailable for many patients. Recent breakthroughs in therapeutic gene-editing have…
Read the article →Pharmaceutics2026ReviewNon-viral Gene DeliveryDrug Delivery
Anwer K, Sood S, Sparks J, Faller Dv, Limon A, Lindborg Sr
Interleukin-12 (IL-12) is a potent immunostimulatory cytokine with well-established antitumor activity, but systemic recombinant IL-12 administration has been constrained by inflammatory toxicity, high circulating cytokine peaks, and insufficient tumor-local exposure. IMNN-001 is a non-viral IL-12 gene therapy…
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