Advanced materials (Deerfield Beach, Fla.)2026ResearchDrug Delivery
Knol Ra, Hu B, Bobylev Eo, Farber M, Laan Pcm, Kock Tjf, Et Al.
Inorganic anticancer drugs such as cisplatin remain central to chemotherapy but are limited by poor tumor selectivity, rapid clearance, and off-target toxicity. We recently developed cationic Pt 2 L 4 nanocages with 12-fold higher anticancer activity than cisplatin in PC-3M-Pro4 cells in vitro, but their positive…
Read the article →Nanomedicine (London, England)2026ReviewDrug Delivery
Aafreen S, Abdur Rehman S, Parvez Barbhuiya T, Rizg Wy, Alghamdi Ma, Md S, Et Al.
Skin cancer is among the most common malignancies worldwide, with a rising global incidence. Cancer develops through complex molecular and genetic changes. Current treatments, such as surgery, chemotherapy, targeted therapy, radiation, and immunotherapy, offer hope. However, challenges like immune evasion, drug…
Read the article →Materials today. Bio2026ReviewDrug Delivery
Liu X, Li C, Xu Z, Yan Y, Liu W, Li Y, Et Al.
This review focuses on the application of magnetic nanorobots (MNRs) in tumor therapy. We first introduce the MNR-mediated drug delivery strategy, which loads anti-tumor agents and actively targets tumor sites. Leveraging the unique physicochemical properties of their constituent materials, MNRs enable controlled…
Read the article →Science translational medicine2026ResearchNon-viral Gene Delivery
Mccormack Nm, Lee-Diaz S, Reyes Tr, Hogarth Mw, Covington Jl, Bragg Ca, Et Al.
Limb-girdle muscular dystrophy type R2 (LGMDR2) is a genetic disorder characterized by progressive skeletal muscle weakness and degeneration. It is caused by mutations in the DYSF gene, which prevent dysferlin expression. Dysferlin protein is essential for muscle cell membrane repair. Gene therapy using…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Gharatape A, Alikhanian A, Verdi J, Choonara Ye, Faridi-Majidi R
Although therapeutic opportunities beyond the scope of either field alone are offered by the combination of immune cell treatment and nanotechnology, a dominant nanoparticle design for immune-cell engineering has not been yielded by two decades of research. Here, it is contended that this lack of advancement is the…
Read the article →Frontiers in genome editing2026ResearchNon-viral Gene Delivery
Yu Z, Li J, Liu M, Qi Q, Duan Z, Yang Z, Et Al.
Prime editing (PE) enables precise genome modifications without double-strand breaks, yet its application in large mammals has been hindered by low efficiency and the technical bottlenecks of zygote microinjection. This study aimed to establish a scalable PE platform in sheep via the direct electroporation of a PE3…
Read the article →Frontiers in pharmacology2026ReviewNon-viral Gene DeliveryDrug Delivery
Rachamala Hk, Atla S, Angom Rs
Cancer immunotherapy is a transformative technology allowing for the elimination of malignant cells through immune system stimulation; however, the large-scale clinical application of adoptive cellular therapy technologies is limited due to difficulties in ex vivo immune cell engineering, high costs, and complicated…
Read the article →Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery
Ramamurthy A, Scimonelli G, Murphy Wl, Saha K
Human T cells modified with nucleic acids constitute a powerful and emerging therapeutic modality for cancer, autoimmune disorders, and aging-related diseases. However, delivering nucleic acids, such as mRNA encoding synthetic receptors, transcription factors, cytokines, or genome editors to T cells can be…
Read the article →Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery
Jacobs W, De Zwaan K, Rutten L, Van Wessel T, Boltje Tj, Cano Lq, Et Al.
Non-viral nanocarriers for oligonucleotide delivery have enormous therapeutic potential, but the factors determining cell type-specific uptake remain incompletely understood. One major cell surface component that delivery vectors encounter is the glycocalyx. While membrane glycans are established interactors for many…
Read the article →Angewandte Chemie (International ed. in English)2026ResearchNon-viral Gene DeliveryDrug Delivery
Gan J, Wang Y, Li M, Cui S, Zhu L, Yu X, Et Al.
Lipid nanoparticles (LNPs) have emerged as a promising platform for gene/drug delivery in cancer therapy, however their nonspecific biodistribution and extensive hepatosplenic sequestration result in insufficient intratumoral accumulation, thereby undermining the therapeutic efficacy. Here, we establish a sequential…
Read the article →Journal of biomaterials science. Polymer edition2026ReviewNon-viral Gene DeliveryDrug Delivery
Maheshwari T, Bhattacharya S, Singh D
About 80-90% of sporadic instances of colorectal cancer (CRC) are caused by mutations in the adenomatous polyposis coli (APC) gene, which is one of the earliest and most common molecular events. The constitutive activation of the Wnt/β-catenin signalling pathway caused by APC dysfunction promotes unchecked cellular…
Read the article →Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery
Nasr Ss, Tabah Oe, Kumar S, Poore S, Duncan Ga
Pulmonary delivery of lipid nanoparticles (LNPs) remains an area of significant interest, given the broad range of genetic disorders that could be addressed through localized administration of therapeutic nucleic acids to the lung. In this study, we investigated how incorporation of the clinically used lung…
Read the article →Frontiers in pharmacology2026ReviewDrug Delivery
Yuan Y, Xie C, Huang Y, Xi J, Wang P, Chen Z, Et Al.
Stroke ranks among the leading global causes of mortality and permanent disability. Its secondary brain injury arises from multiple interrelated pathological cascades, including oxidative stress, neuroinflammation, disrupted autophagy-apoptosis balance, excitotoxicity, iron dyshomeostasis, and blood-brain barrier…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Zhang H, Guo J, Wang X, Shen Y, Yao Y, Ghadage Ss, Et Al.
The clinical translation of cancer nanomedicine remains constrained by inefficient intracellular delivery, poor subcellular specificity, and limited tumor accumulation, highlighting the need for more precise drug delivery strategies. Organelle-targeted nanocarriers have emerged as a promising platform for enhancing…
Read the article →Research Square (preprint)2026ResearchNon-viral Gene DeliveryDrug Delivery
Gond C, Verma A, Singh P, Singh D, Tiwari Ak
The process of delivering bioactive medication ingredients into a patient's body is known as drug delivery. To create drug delivery systems (DDs), a range of natural resources and synthetic materials derived from natural resources can be used as building blocks. These DDs include liposomal systems, which are composed…
Read the article →Frontiers in oncology2026ReviewDrug Delivery
Beaugé L, Ibarra Le
Photo-assisted therapies have emerged as promising strategies for cancer treatment by combining localized tumor ablation with the induction of systemic antitumor immune responses. Despite encouraging preclinical and clinical advances, their therapeutic efficacy remains limited by the unfavorable pharmacokinetics…
Read the article →International journal of nanomedicine2026ResearchNon-viral Gene DeliveryDrug Delivery
Rodrigues Alves Mt, Da Silva Wn, Azevedo Gv, Carvalho Costa Pa, Silva Gh, Figueiredo Mm, Et Al.
Lipid nanoparticles (LNPs) have enabled the clinical translation of nucleic acid therapeutics, and their composition plays a critical role in organ targeting and route-specific delivery. Intranasal (IN) administration offers direct access to the lungs, while reducing systemic exposure. However, designing LNPs capable…
Read the article →Research Square (preprint)2026ResearchNon-viral Gene DeliveryDrug Delivery
Nguyen A, Jiang M, Müller Jt, Molbay M, Carneiro Sp, Matzek D, Et Al.
Asthma continues to pose a major clinical burden despite the availability of modern biologic therapies. In eosinophilic asthma, the transcription factor GATA3 is a key regulator of Th 2 differentiation and type 2 cytokine production and therefore represents an attractive target for siRNA-based intervention. We…
Read the article →ACS applied bio materials2026ResearchDrug Delivery
Kumar A, Patri Sv, Chilumula S, Arjunan P, Ayyanar V, Hanchate P, Et Al.
The clinical effectiveness of doxorubicin (DOX) in hepatocellular carcinoma (HCC) remains constrained by poor tumor selectivity and the emergence of multidrug resistance. In this work, we examine how the electronic nature of the C-5 substituent on uracil-based nucleoside lipids shapes the physicochemical and…
Read the article →Translational research : the journal of laboratory and clinical medicine2026ReviewDrug Delivery
Kausar T, Ahmed W, Shafiq T, Kausar R, Liang Y, Duan L
Nanomedicine represents one of the pivotal technologies that further bridges critical gaps in precision theranostics through targeted delivery, integrated diagnostics and therapeutics, and personalized treatment. Among various nanocarriers, extracellular vesicles (EVs) have attracted substantial interest owing to…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Li X, Yu Y, Xie Y, He P, Chen Y, Guo Z, Et Al.
Macrophages are highly plastic immune cells with tumor-homing capacity and immunomodulatory functions, making macrophage-based nanoplatforms attractive for cancer immunotherapy. Macrophage-based nanoplatforms include macrophage-derived extracellular vesicles (EVs), macrophage membrane-coated nanoparticles, and live…
Read the article →Advances in Colloid and Interface Science2026ReviewNon-viral Gene DeliveryDrug Delivery
D Zhi, A Halemaimaiti, B Dai, H Li, H Wang, Z Zhang, J Yu, S Zhang
This review examines how lipid structure and formulation affect the delivery of DNA, mRNA and siRNA by lipid nanoparticles, while assessing tissue targeting, safety and clinical translation challenges.
Read the article →BioDrugs2026ReviewNon-viral Gene DeliveryDrug Delivery
U Iqbal, Rw Hwang, Wj Costain
A review of blood–brain barrier transport mechanisms and emerging lipid nanoparticle strategies for carrying nucleic acid and other complex therapies into the central nervous system.
Read the article →Small2025ReviewNon-viral Gene DeliveryDrug Delivery
S Sarmah, S Baidya, M De
This review surveys lipid nanoparticle composition, ionisable lipid synthesis and strategies to target delivery of fragile RNA therapeutics while addressing tissue selectivity and immune activation.
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